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In these clinical trials, the combination of dasatinib with midostaurin was generally well tolerated with manageable adverse events in the majority of patients. One unique feature of this combination was delayed myelosuppression, which appeared to be due to the unique mechanism of action of dasatinib. Dasatinib inhibits a range of platelet tyrosine kinases including Src family members, Fyn, Btk, and Lyn, all of which are involved in signaling pathways that are important for platelet homeostasis.42-45 This drug combination was well tolerated in early-phase clinical trials of patients with AML or CML,45 and more importantly, in the phase II randomized trial of adult patients with newly diagnosed AML, which demonstrated a significant improvement in complete remission rates with this combination over chemotherapy alone.46,47
In summary, the data suggest that FLT3-ITD expression determines the response to FLT3 inhibitors. Our data suggest that low FLT3-ITD allele burden identifies patients with AML with no obvious actionable molecular abnormalities that may respond to more intensive therapy. A phase 2 study of the FLT3 inhibitor AG-1024 in FLT3-ITD+ AML with such low allele burden is ongoing. In addition, the emergence of resistance to FLT3 inhibitors should be considered, particularly in FLT3-ITD+ AML patients that have a low FLT3-ITD allele burden. Thus, residual disease in FLT3-ITD+ AML patients should be further evaluated by MRD to select patients for further therapy.
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I am running a PC with Windows 7 and Adobe Photoshop CS6. I am wondering how to end the trial period and convert to a full copy of Photoshop CS6. I tried closing down Photoshop, which produced a message telling me to return the disk. I did that, but the same message returned. How can I end this?
Hi Dave,I was able to get my English Indesign CS6 to switch to German. But there is one Problem. The moment I startet Indesign there is the error message that my trial version ends soon altough I bougt a regular Version with correct serial number by an adobe seller. Can anybody help me? 827ec27edc